The gradual release of antibodies and antimicrobial substances (lysozyme, ovomucine and ovotransferine) make the Dentoimmune Solution an effective therapeutic tool in the sterilization and irrigation of the root canals and can be used in combination with various canal pastes (with calcium hydroxide, calcium silicate, antibiotics). It can also be used for the prevention of postoperative complications in surgical interventions (implantology, periodontics, dental extractions, bone augmentation, apical resections, odontectomies, alveolites, etc.), applied directly to the surgical site and can also be associated with other therapeutic substances (antibiotics, augmenting material of all kinds, PRP, A-PRF, I-PRF, L-PRF, PRGF, etc.). Dentoimmune Solution is also an effective therapeutics in sterilizing periodontal pockets. In addition, due to its rich collagen and protein composition with a strong proliferation effect and differentiation of fibroblasts, Dentimmune Solution helps restore gingival mucosa affected by periodontal disease, aphtha, or other types of lesions and can also be successfully used as surgical dressing after various interventions in the oral cavity (periodontics, implantology, dental extractions, etc.).

  • Prospect


Blood antibodies production in birds and the extraction of egg yolk specific antibodies has become an attractive subject for specialists, as evidenced by the increase in research volume and literature on IgY. The results of in vitro and in vivo studies on immunoglobulins (Y) extracted from egg yolk (Gallus domesticus) have become a great hope in preventing and fighting a large number of human diseases. Interest in immunoglobulins prepared on the hen is currently high due to the increasing incidence of antibiotic-resistant bacteria. IgY gains much attention from specialists due to structural differences from mammalian IgG and reactivity in the human body. The special features of this product create a hope for medicine, IgY being used in many areas of activity. Within the research program, studies are carried out on the procedures for obtaining IgY under laboratory and production conditions. At the same time, experiments were carried out on the purification of IgY and the specificity of these immunoglobulins was studied against the antigens that were used to immunize the hens. Biological products containing specific IgY are monovalent or polyvalent.  Y immunoglobulins were obtained from the isolated bacteria samples collected from patients who presented themselves in our dental clinic with many of these bacteria proving antibiotic resistant.  Laboratory tests have been performed on IgY-specific efficacy against antibiotic-resistant bacteria isolated from patients. The results of the experiments conducted so far show that specific IgY inhibit in vitro the multiplication of antibiotic-resistant bacteria. Depending on the intensity of the specific inhibited bacterial multiplication, as well as on the inhibition time in vitro, therapeutic behavior can be established. Under these conditions, single-dose treatment at 24 hours or fractionalized doses at different time intervals may occur. Recent in vitro information on IMUNOINSTANT products against isolated bacteria from patients allows for more effective treatment programs for humans, IgY inhibiting specific large amounts of pathogenic germs, whose action is thus neutralized. For this purpose, treatment should be permanently controlled by laboratory means, and the program should be monitored appropriately. Preventive treatment with IgY will be determined based on isolated bacteria and incidence. Depending on their number, a polyvalent IgY comprising immunoglobulins specific for each bacterial species will be prepared.